IgA Nephropathy is usually a slow-moving progressive kidney disease that after years may lead to kidney failure. Matthew has the most aggressive form of IgA Nephropathy, which destroys the kidneys quickly. In barely a year since his diagnosis, IgA Nephropathy has so destroyed his kidneys that medication can no longer help him. He must have a transplant to survive.
IgA nephropathy develops when IgA, proteins that help the body fight infections, settle in the kidneys. After many years, the IgA deposits may cause the kidneys to leak blood and sometimes protein in the urine.
If you're interested in more information on IgA Nephropathy, the National Institute of Health, the Mayo Clinic, and the Foundation for IgA Nephropathy provide details on the condition and its effects.